Kanna

A succulent plant native to South Africa, Kanna (Sceletium tortuosum) has a long history of traditional use for enhancing mood, reducing anxiety, and promoting emotional well-being. Revered by indigenous cultures, especially the Khoisan peoples, Kanna has gained attention in modern herbal and wellness circles as a natural mood enhancer and social aid.

Botanical Information

Scientific Name: Sceletium tortuosum
Family: Aizoaceae
Native Regions: Arid and semi-arid regions of South Africa, particularly the Western and Northern Cape provinces

Kanna is a hardy, drought-resistant succulent that thrives in sandy soils and full sun. Its fleshy leaves and star-shaped flowers make it visually distinct, but it is the plant’s psychoactive properties that have made it culturally significant for centuries.

Active Compounds

Kanna contains several biologically active mesembrine alkaloids, which are responsible for its mood-enhancing and anxiolytic effects:

Mesembrine – A potent serotonin reuptake inhibitor (SRI)
Mesembrenone – Exhibits phosphodiesterase-4 (PDE4) inhibition
Mesembrenol and Tortuosamine – Contribute to calming and cognitive effects

These compounds interact primarily with the central nervous system, promoting a state of calm focus, emotional openness, and reduced stress.

Traditional Uses and Benefits

Traditional Uses:
Kanna was traditionally chewed, smoked, snuffed, or used as a tea by the Khoisan people of South Africa. It was often used during social gatherings, hunting expeditions, or spiritual ceremonies to enhance mood, reduce fear, and increase mental clarity.

Potential Benefits (based on traditional and emerging research):

Elevates mood and reduces symptoms of mild depression or anxiety
Enhances sociability and emotional connection in social settings
Supports cognitive function and mental focus
May aid in stress resilience and emotional regulation

Preparation & Dosage

Common Methods of Use:

Capsules: Convenient for standardized daily use
Tincture: Liquid extract taken under the tongue or added to drinks
Tea: Infused with hot water, though milder in effect
Fermented powder (kougoed): Traditional preparation with stronger psychoactive properties

Suggested Dosage (Standardized Extract):

50–200 mg per day, depending on sensitivity and desired effects
Start low (e.g., 50 mg) and increase gradually if needed

Effects may be felt within 30–60 minutes and typically last 4–6 hours depending on the form used.

Additional Notes

Interactions: Do not combine Kanna with SSRIs, MAOIs, or other antidepressants due to the risk of serotonin syndrome.
Legal Status: Kanna is legal in most countries, including the EU and U.S., but always check local regulations.
Storage: Store in a cool, dry place away from sunlight to preserve potency.